The organic chemistry of drug design and drug action . Richard B. Silverman
ISBN: 0126437327,9780126437324 | 646 pages | 17 Mb
The organic chemistry of drug design and drug action Richard B. Silverman
Publisher: Academic Press
Knowledge of the rate of action of compounds against cultured malaria parasites is required to determine the optimal time-points for drug mode of action studies, as well as to predict likely in vivo parasite clearance rates in order to select optimal hit compounds for further development. We give a comprehensive assessment of the analytical tools of network topology and dynamics. The organic chemistry of drug design and drug action by Richard B. The state-of-the-art use of chemical similarity, protein structure, protein-protein interaction, signaling, genetic interaction and metabolic networks in the discovery of drug targets is summarized. Therefore, combinatorial drug design, whereby inhibitors of signaling networks are targeted to specific subcellular compartments, may generate effective anticancer drugs with novel mechanisms of action. Silverman Download The organic chemistry of drug design and drug action The organic chemistry of drug design and. This multivolume work covers This reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians, including practitioners and physicians. Network description and analysis not only give a systems-level understanding of drug action and disease complexity, but can also help to improve the efficiency of drug design. The Organic Chemistry of Drug Design and Drug Action, Second Edition. The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction in patients. In this study Large-scale screens of synthetic chemical libraries have been especially successful in identifying numerous early hit compounds against cultured parasites . See the related Commentary The chemical synthesis of Gamitrinib is described in detail in the Supplemental Data and Supplemental Figure 1 (supplemental material available online with this article; doi:10.1172/JCI37613DS1).
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